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Article

Recovery of phenotypes obtained by adaptive evolution through inverse metabolic engineering.

Applied and environmental microbiology - 1 Nov 2012

Hong Kuk-Ki, Nielsen Jens

Abstract excerpt

In a previous study, system level analysis of adaptively evolved yeast mutants showing improved galactose utilization revealed relevant mutations. The governing mutations were suggested to be in the Ras/PKA signaling pathway and ergosterol metabolism. Here, site-directed mutants having one of the mutations RAS2(Lys77), RAS2(Tyr112), and ERG5(Pro370) were constructed and evaluated. The mutants were also combined...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22904057
DOI: 10.1128/AEM.01444-12
PMCID: PMC3485731

Genes

PGM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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