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DNA methylation of long noncoding RNA cytochrome B in diabetic retinopathy

16 Dec 2024

Abstract excerpt

Diabetic retinopathy, a microvascular complication of diabetes, is the leading cause of blindness in adults, but the molecular mechanism of its development remains unclear. Retinal mitochondrial DNA is damaged and hypermethylated, and mtDNA-encoded genes are downregulated. Expression of a long noncoding RNA (larger than 200 nucleotides, which does not translate into proteins), encoded by mtDNA, cytochrome B (Lnc...

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PMID: 39811245
DOI: 10.1016/j.ncrna.2024.12.007

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