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Article

Epigenetic Modification of Mitochondrial DNA in the Development of Diabetic Retinopathy

4 Aug 2015

Abstract excerpt

PURPOSE: Retinal mitochondria are dysfunctional in diabetes, and mitochondrial DNA (mtDNA) is damaged and its transcription is compromised. Our aim was to investigate the role of mtDNA methylation in the development of diabetic retinopathy. METHODS: Effect of high glucose (20 mM) on mtDNA methylation was analyzed in retinal endothelial cells by methylation-specific PCR and by quantifying 5-methylcytosine (5mC)....

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PMID: 26241401
DOI: 10.1167/iovs.15-16937

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