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Article

Lactic acidosis induces metabolic and phenotypic reprogramming in cholangiocarcinoma cells via the upregulation of thrombospondin-1.

Cancer science - 1 Apr 2023

Thamrongwaranggoon Ubonrat, Kuribayashi Kanji, Araki Hirotaka, Hino Yuko, Koga Tomoaki, Seubwai Wunchana, Wongkham Sopit, Nakao Mitsuyoshi, Hino Shinjiro

Abstract excerpt

The high glycolytic activity of cancer cells leads to lactic acidosis (LA) in the tumor microenvironment. LA is not merely a consequence of metabolic activities but also has functional roles in metabolic reprogramming and cancer progression. Cholangiocarcinoma (CCA) cells exhibit a high dependency on glycolysis for survival and growth, but the specific effects of LA on cellular characteristics remain unknown....

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Source

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Identifiers

PMID: 36562400
DOI: 10.1111/cas.15699
PMCID: PMC10067391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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