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Article

Conserved Double Translation Initiation Site for Δ160p53 Protein Hints at Isoform's Key Role in Mammalian Physiology.

International journal of molecular sciences - 13 Dec 2022

López-Iniesta Maria José, Parkar Shrutee N, Ramalho Ana Catarina, Lacerda Rafaela, Costa Inês F, Zhao Jingyuan, Romão Luísa, Candeias Marco M

Abstract excerpt

p53 is the most commonly mutated gene in human cancers. Two fundamental reasons for this are its long protein isoforms protect from cancer, while its shorter C-terminal isoforms can support cancer and metastasis. Previously, we have shown that the Δ160p53 protein isoform enhances survival and the invasive character of cancer cells. Here, we identified a translation initiation site nine codons downstream of codon...

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Identifiers

PMID: 36555484
DOI: 10.3390/ijms232415844
PMCID: PMC9779343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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