Article
The Educational Program of Macrophages toward a Hyperprogressive Disease-Related Phenotype Is Orchestrated by Tumor-Derived Extracellular Vesicles.
International journal of molecular sciences - 13 Dec 2022
Indino Serena, Borzi Cristina, Moscheni Claudia, Sartori Patrizia, De Cecco Loris, Bernardo Giancarla, Le Noci Valentino, Arnaboldi Francesca, Triulzi Tiziana, Sozzi Gabriella, Tagliabue Elda, Sfondrini Lucia, Gagliano Nicoletta, Moro Massimo, Sommariva Michele
Abstract excerpt
Hyperprogressive disease (HPD), an aggressive acceleration of tumor growth, was observed in a group of cancer patients treated with anti-PD1/PDL1 antibodies. The presence of a peculiar macrophage subset in the tumor microenvironment is reported to be a sort of "immunological prerequisite" for HPD development. These macrophages possess a unique phenotype that it is not clear how they acquire. We hypothesized that...
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