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Article

Hydroxychloroquine Mitigates Dilated Cardiomyopathy Phenotype in Transgenic D94A Mice.

International journal of molecular sciences - 9 Dec 2022

Kanashiro-Takeuchi Rosemeire M, Kazmierczak Katarzyna, Liang Jingsheng, Takeuchi Lauro M, Sitbon Yoel H, Szczesna-Cordary Danuta

Abstract excerpt

In this study, we aimed to investigate whether short-term and low-dose treatment with hydroxychloroquine (HCQ), an antimalarial drug, can modulate heart function in a preclinical model of dilated cardiomyopathy (DCM) expressing the D94A mutation in cardiac myosin regulatory light chain (RLC) compared with healthy non-transgenic (NTg) littermates. Increased interest in HCQ came with the COVID-19 pandemic, but the...

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Identifiers

PMID: 36555229
DOI: 10.3390/ijms232415589
PMCID: PMC9779604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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