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Article

N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene.

Human molecular genetics - 1 Oct 2018

Rodriguez Blanca Morales, Khouzami Lara, Decostre Valérie, Varnous Shaida, Pekovic-Vaughan Vanja, Hutchison Christopher J, Pecker Françoise, Bonne Gisèle, Muchir Antoine

Abstract excerpt

Cardiomyopathy caused by lamin A/C gene (LMNA) mutations (hereafter referred as LMNA cardiomyopathy) is an anatomic and pathologic condition associated with muscular and electrical dysfunction of the heart, often leading to heart failure-related disability. There is currently no specific therapy available for patients that target the molecular pathophysiology of LMNA cardiomyopathy. We showed here an increase in...

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Source

Identifiers

PMID: 29982513
DOI: 10.1093/hmg/ddy243

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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