Article
A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function.
Scientific reports - 4 Apr 2018
Trubiroha A, Gillotay P, Giusti N, Gacquer D, Libert F, Lefort A, Haerlingen B, De Deken X, Opitz R, Costagliola S
Abstract excerpt
The foregut endoderm gives rise to several organs including liver, pancreas, lung and thyroid with important roles in human physiology. Understanding which genes and signalling pathways regulate their development is crucial for understanding developmental disorders as well as diseases in adulthood. We exploited unique advantages of the zebrafish model to develop a rapid and scalable CRISPR/Cas-based mutagenesis...
Topics
Join the communities discussing this publication.