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Article

Longevity is not influenced by prenatal programming of body size.

Aging cell - 1 Aug 2010

Conover Cheryl A, Bale Laurie K, Grell Jacquelyn A, Mader Jessica R, Mason Megan A

Abstract excerpt

Insulin-like growth factor (IGF) signaling is essential for achieving optimal body size during fetal development, whereas, in the adult, IGFs are associated with aging and age-related diseases. However, it is unclear as to what extent lifespan is influenced by events that occur during development. Here, we provide direct evidence that the exceptional longevity of mice with altered IGF signaling is not linked to...

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Identifiers

PMID: 20550518
DOI: 10.1111/j.1474-9726.2010.00589.x
PMCID: PMC3072285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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