Article
Characterization of a dominant negative C. elegans Twist mutant protein with implications for human Saethre-Chotzen syndrome.
Development (Cambridge, England) - 1 Jun 2002
Corsi Ann K, Brodigan Thomas M, Jorgensen Erik M, Krause Michael
Abstract excerpt
Twist is a transcription factor that is required for mesodermal cell fates in all animals studied to date. Mutations of this locus in humans have been identified as the cause of the craniofacial disorder Saethre-Chotzen syndrome. The Caenorhabditis elegans Twist homolog is required for the development of a subset of the mesoderm. A semidominant allele of the gene that codes for CeTwist, hlh-8, has defects that...
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