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Article

A Twist-Box domain of the C. elegans Twist homolog, HLH-8, plays a complex role in transcriptional regulation.

Genetics - 9 Aug 2023

Gruss Michael J, O'Callaghan Colleen, Donnellan Molly, Corsi Ann K

Abstract excerpt

TWIST1 is a basic helix-loop-helix (bHLH) transcription factor in humans that functions in mesoderm differentiation. TWIST1 primarily regulates genes as a transcriptional repressor often through TWIST-Box domain-mediated protein-protein interactions. The TWIST-Box also can function as an activation domain requiring 3 conserved, equidistant amino acids (LXXXFXXXR). Autosomal dominant mutations in TWIST1, including...

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Identifiers

PMID: 37067863
DOI: 10.1093/genetics/iyad066
PMCID: PMC10411555

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