Article
Prevalence and clinical implications of germline mutations among Jordanian patients with ovarian cancer. The Jordanian exploratory cancer genetics (Jo-ECAG) ovarian study.
Molecular genetics & genomic medicine - 1 Apr 2023
Abdel-Razeq Hikmat, Al-Azzam Khansa, Elemian Shatha, Abu-Fares Hala, Abu Sheikha Areej, Bani Hani Hira, Bater Rayan, Sharaf Baha', Heald Brandie, Esplin Edward D, Nielsen Sarah M, Alkyam Mais, Abujamous Lama, Al-Attary Areej
Abstract excerpt
BACKGROUND: Ovarian cancer is one of the most common gynecological malignancies. Due to the absence of effective screening methods, ovarian cancer is usually diagnosed at late stages. Patients with pathogenic and likely-pathogenic germline variants (PGVs) in BRCA1 or BRCA2 harbor elevated risk of developing both ovarian and breast cancers. Identifying PGVs may help in both cancer prevention and active disease...
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