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Low BRCA1 and BRCA2 Germline Mutation Rates in a French-Canadian Population with a Diagnosis of Epithelial Tubo-Ovarian Carcinoma.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC - 1 Oct 2022

Bernard Juliette, Mehros Wala, Gregoire Jean, Douville Pierre, Renaud Marie-Claude, Sebastianelli Alexandra, Langlais Eve-Lyne, Plante Marie

Abstract excerpt

OBJECTIVE: Universal genetic testing has become increasingly important in the management of epithelial tubo-ovarian and peritoneal carcinoma. Worldwide, reported incidences of deleterious BRCA mutations vary between 12% and 15%. We sought to evaluate the incidence in our population, given its specific genetic background (French-Canadian ancestry). METHOD: Mainstream genetic testing was implemented in our service...

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PMID: 35779836
DOI: 10.1016/j.jogc.2022.06.005

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