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Article

Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells

14 Dec 2022

Abstract excerpt

Cannabidiol (CBD), one of the major cannabinoids in the plant Cannabis sativa L., is the active ingredient in a drug approved for the treatment of seizures associated with certain childhood-onset epileptic disorders. CBD has been shown to induce male reproductive toxicity in multiple animal models. We previously reported that CBD inhibits cellular proliferation in the mouse Sertoli cell line TM4 and in primary...

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PMID: 36519830
DOI: 10.1093/toxsci/kfac131

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