Article
A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis.
Human molecular genetics - 1 Jul 2017
Munz Matthias, Willenborg Christina, Richter Gesa M, Jockel-Schneider Yvonne, Graetz Christian, Staufenbiel Ingmar, Wellmann Jürgen, Berger Klaus, Krone Bastian, Hoffmann Per, van der Velde Nathalie, Uitterlinden André G, de Groot Lisette C P G M, Sawalha Amr H, Direskeneli Haner, Saruhan-Direskeneli Güher, Guzeldemir-Akcakanat Esra, Keceli Huseyin Gencay, Laudes Matthias, Noack Barbara, Teumer Alexander, Holtfreter Birte, Kocher Thomas, Eickholz Peter, Meyle Jörg, Doerfer Christof, Bruckmann Corinna, Lieb Wolfgang, Franke Andre, Schreiber Stefan, Nohutcu Rahime M, Erdmann Jeanette, Loos Bruno G, Jepsen Soeren, Dommisch Henrik, Schaefer Arne S
Abstract excerpt
Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. The disease is characterized by destruction of the alveolar bone due to an aberrant host inflammatory response to a dysbiotic oral microbiome. Previous genome-wide association studies (GWAS) have reported several suggestive susceptibility loci. Here, we...
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