Article
A Single Variant in Pri-miRNA-155 Associated with Susceptibility to Hereditary Breast Cancer Promotes Aggressiveness in Breast Cancer Cells.
International journal of molecular sciences - 6 Dec 2022
Landeros Natalia, Gonzalez-Hormazabal Patricio, Pérez-Moreno Pablo, Tapia Julio C, Jara Lilian
Abstract excerpt
Variants in genes encoding for microRNAs have been associated with their deregulation in breast cancer (BC). Sequencing of microRNAs deregulated in BC was performed using DNA from Chilean patients with a strong family history and negative for mutations in BRCA1/BRCA2. Seventeen variants were identified, three of which were selected for a case-control association study: rs376491654 (miR-335), rs755634302...
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