Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two novel variants in the 3'UTR of the BRCA1 gene in familial breast and/or ovarian cancer.

Breast cancer research and treatment - 1 Feb 2011

Lheureux Stéphanie, Lambert Bernard, Krieger Sophie, Legros Angelina, Vaur Dominique, Denoyelle Christophe, Berthet Pascaline, Poulain Laurent, Hardouin Agnès

Abstract excerpt

For the majority of breast and/or ovarian cancer patients tested for BRCA1/2 genes, mutation screening of the coding regions remains negative. MicroRNAs which negatively regulate mRNA translation by binding to 3' untranslated region (3'UTR) are implicated in cancer. Genetic changes in the 3'UTR of several genes were reported to be associated with higher susceptibility to particular tumor types. The aim of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Family Health

Share to Gene Deletion

Share to Genes, BRCA1

Share to Luciferases

Share to MicroRNAs

Share to Ovarian Neoplasms

Source

Identifiers

PMID: 20848184
DOI: 10.1007/s10549-010-1165-8

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two novel variants in the 3'UTR of the BRCA1 gene in familial breast and/or ovarian cancer.PMID 20848184Read ↗

Rare BRCA1 haplotypes including 3'UTR SNPs associated with breast cancer risk.Semantic proximity Read ↗

Identification of fifteen novel germline variants in the BRCA1 3'UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site.Semantic proximity Read ↗

Evaluation of genetic variations in miRNA-binding sites of BRCA1 and BRCA2 genes as risk factors for the development of early-onset and/or familial breast cancer.Semantic proximity Read ↗

Identification of a novel disease-associated variant in the BRCA1 3’UTR that introduces a functional miR-103 target siteSemantic proximity Read ↗

Targeted resequencing of the microRNAome and 3'UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer.Semantic proximity Read ↗

Assessment of the functional impact of germline BRCA1/2 variants located in non-coding regions in families with breast and/or ovarian cancer predisposition.Semantic proximity Read ↗

The BRCA1 3'-UTR: 5711+421T/T_5711+1286T/T genotype is a possible breast and ovarian cancer risk factor.Semantic proximity Read ↗

A Dominantly Inherited 5' UTR Variant Causing Methylation-Associated Silencing of BRCA1 as a Cause of Breast and Ovarian Cancer.Semantic proximity Read ↗

The role of microRNAs in cancer susceptibility.Semantic proximity Read ↗

Mutation screening of MIR146A/B and BRCA1/2 3'-UTRs in the GENESIS study.Semantic proximity Read ↗

Identification of a novel splice-site mutation of the BRCA1 gene in two breast cancer families: screening reveals low frequency in Icelandic breast cancer patients.Semantic proximity Read ↗

A Germline Mutation in the BRCA1 3’UTR Variant Predicts Susceptibility to Breast Cancer in a Saudi Arabian PopulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.