Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two Single Nucleotide Polymorphisms in the Purinergic Receptor P2X7 Gene Are Associated with Disease Severity in Multiple Sclerosis.

International journal of molecular sciences - 6 Dec 2022

Guerini Franca Rosa, Agliardi Cristina, Bolognesi Elisabetta, Zanzottera Milena, Caputo Domenico, Pasanisi Maria Barbara, Rovaris Marco, Clerici Mario

Abstract excerpt

Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) that leads to progressive physical disability. Recent evidence has suggested that P2X7 receptor (P2X7R)-mediated purinergic signalling pathways play a role in MS-associated neuroinflammation, possibly contributing to disease pathogenesis. To evaluate possible associations between P2X7R polymorphisms and MS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine and Purinergic Signaling
Share to Adolescent and Pediatric Healthcare

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Multiple Sclerosis

Share to Patient Acuity

Share to Polymorphism, Single Nucleotide

Share to Polyomavirus and related diseases

Share to Receptors, Purinergic P2X7

Source

Open in PubMed Open full text

Identifiers

PMID: 36499708
DOI: 10.3390/ijms232315381
PMCID: PMC9736555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two Single Nucleotide Polymorphisms in the Purinergic Receptor P2X7 Gene Are Associated with Disease Severity in Multiple Sclerosis.PMID 36499708Read ↗

Purinergic receptors P2RX4 and P2RX7 in familial multiple sclerosis.Semantic proximity Read ↗

A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis.Semantic proximity Read ↗

Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection.Semantic proximity Read ↗

Association study of two functional single nucleotide polymorphisms of neuropeptide y gene with multiple sclerosis.Semantic proximity Read ↗

Gain-of-function of P2X7 receptor gene variants in multiple sclerosis.Semantic proximity Read ↗

Association study of rs7799039, rs1137101 and rs8192678 gene variants with disease susceptibility/severity and corresponding LEP, LEPR and PGC1A gene expression in multiple sclerosis.Semantic proximity Read ↗

P2X7 receptor gene polymorphism analysis in rheumatoid arthritis.Semantic proximity Read ↗

Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.Semantic proximity Read ↗

Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.Semantic proximity Read ↗

The T244I variant of the interleukin-7 receptor-alpha gene and multiple sclerosis.Semantic proximity Read ↗

Osteopontin gene and clinical severity of multiple sclerosis.Semantic proximity Read ↗

Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.