Article
TIMP3 Gene Polymorphisms of -1296 T > C and -915 A > G Increase the Susceptibility to Arsenic-Induced Skin Cancer: A Cohort Study and In Silico Analysis of Mutation Impacts
International journal of molecular sciences - 29 Nov 2022
Wu Meei-Maan, Chen Chi-Wei, Chen Chiu-Yi, Lee Chih-Hung, Chou Mark, Hsu Ling-I, Lee Te-Chang, Chen Chien-Jen
Abstract excerpt
Long-term exposure to arsenic may induce several human cancers, including non-melanoma skin cancer. The tissue inhibitor of metalloproteinase (TIMP)-3, encoded by the TIMP3 gene, may inhibit tumor growth, invasion, and metastasis of several cancer types. In this study, we aimed to investigate effects of the TIMP3 -1296 T > C (rs9619311) and -915 A > G (rs2234921) single-nucleotide polymorphisms (SNPs) on skin...
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