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Article

A computational study to assess the polymorphic landscape of matrix metalloproteinase 3 promoter and its effects on transcriptional activity.

Computers in biology and medicine - 1 Jun 2022

Banik Payel, Majumder Ranabir, Mandal Anik, Dey Sanjib, Mandal Mahitosh

Abstract excerpt

BACKGROUND: Matrix metalloproteinase 3 (MMP3) plays a crucial role in cancer progression and development by proteolyzing extracellular matrix substrates. Primarily, the expression of MMP3 is regulated at the transcriptional level. The minute interplay of various transcription factor binding motifs at the promoter region is responsible for the altered expression of the genes. Single nucleotide polymorphism (SNP)...

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PMID: 35339097
DOI: 10.1016/j.compbiomed.2022.105404

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