Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Underestimated Role of the p53 Pathway in Renal Cancer

22 Nov 2022

Abstract excerpt

The TP53 tumor suppressor gene is known as the guardian of the genome, playing a pivotal role in controlling genome integrity, and its functions are lost in more than 50% of human tumors due to somatic mutations. This percentage rises to 90% if mutations and alterations in the genes that code for regulators of p53 stability and activity are taken into account. Renal cell carcinoma (RCC) is a clear example of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Renal cell carcinoma treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36497215
DOI: 10.3390/cancers14235733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Underestimated Role of the p53 Pathway in Renal CancerPMID 36497215Read ↗

Unraveling the Guardian: p53's Multifaceted Role in the DNA Damage Response and Tumor Treatment Strategies.Semantic proximity Read ↗

The Undervalued Avenue to Reinstate Tumor Suppressor Functionality of the p53 Protein Family for Improved Cancer Therapy - Drug RepurposingSemantic proximity Read ↗

Potential therapeutic targets ofTP53gene in the context of its classically canonical functions and its latest non-canonical functions in human cancerSemantic proximity Read ↗

Tp53 and its potential therapeutic role as a target in bladder cancerSemantic proximity Read ↗

p53 is Functionally Inhibited in Clear Cell Renal Cell Carcinoma (Ccrcc): A Mechanistic and Correlative Investigation into Genetic and Molecular Characteristics.Semantic proximity Read ↗

The p53 NetworkSemantic proximity Read ↗

Exploiting the p53 pathway for cancer diagnosis and therapy.Semantic proximity Read ↗

Functional Diversity of p53 in Human and Wild AnimalsSemantic proximity Read ↗

The p53 pathwaySemantic proximity Read ↗

The p53 tumor suppressor gene and nuclear protein: basic science review and relevance in the management of bladder cancer.Semantic proximity Read ↗

p53 is functionally inhibited in clear cell renal cell carcinoma (ccRCC): a mechanistic and correlative investigation into genetic and molecular characteristics.Semantic proximity Read ↗

The Role of p53 Signaling in Colorectal CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.