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Article

p53 is functionally inhibited in clear cell renal cell carcinoma (ccRCC): a mechanistic and correlative investigation into genetic and molecular characteristics.

Journal of cancer research and clinical oncology - 1 Dec 2021

Diesing Karoline, Ribback Silvia, Winter Stefan, Gellert Manuela, Oster Antonia M, Stühler Viktoria, Gläser Eva, Adler Frank, Hartwig Christoph, Scharpf Markus, Bedke Jens, Burchardt Martin, Schwab Matthias, Lillig Christopher H, Kroeger Nils

Abstract excerpt

PURPOSE: Although p53 is rarely mutated in ccRCC, its overexpression has been linked to poor prognosis. The current study sought to elucidate the unique role of p53 in ccRCC with genomic, proteomic, and functional analyses. MATERIALS AND METHODS: Data from the Cancer Genome Atlas (TCGA) were evaluated for genomic and proteomic characteristics of p53; a tissue micro array (TMA) study was carried out to evaluate...

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Identifiers

PMID: 34499221
DOI: 10.1007/s00432-021-03786-1
PMCID: PMC8557161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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