Article
Clinical characteristics of a patient with de novo acute promyelocytic leukemia with JAK2 v617f mutation.
Hematology (Amsterdam, Netherlands) - 1 Dec 2022
Jiang Yi-Zhi, Wei Zhong-Ling, Wang Na-Na, Huang Chen, Huang Jun, Yan Jia-Wei, Wang Ran, Yu Zheng-Zhi, Huang Dong-Ping
Abstract excerpt
BACKGROUND: The V617F mutation of Janus-associated kinase 2 (JAK2) is common in myeloproliferative neoplasms (MPN). JAK2 V617F mutation can be detected in patients with de novo acute myeloid leukemia (AML), but de novo acute promyelocytic leukemia (APL) with JAK2 V617F mutation is rare. CASE PRESENTATION: We report a case of APL with both the t(15;17) translocation as well as the JAK2 V617F mutation that...
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