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Article

Structural changes in NOTCH3 induced by CADASIL mutations: Role of cysteine and non-cysteine alterations.

The Journal of biological chemistry - 1 Jun 2023

Lee Soo Jung, Zhang Xiaojie, Wu Emily, Sukpraphrute Richard, Sukpraphrute Catherine, Ye Andrew, Wang Michael M

Abstract excerpt

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a cerebral small vessel disease that results from mutations in NOTCH3. How mutations in NOTCH3 ultimately result in disease is not clear, although there is a predilection for mutations to alter the number of cysteines of the gene product, supporting a model in which alterations of conserved disulfide bonds of...

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Identifiers

PMID: 37209821
DOI: 10.1016/j.jbc.2023.104838
PMCID: PMC10318516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural changes in NOTCH3 induced by CADASIL mutations: Role of cysteine and non-cysteine alterations.PMID 37209821Read ↗

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