Article
Single nucleotide polymorphisms of deoxyribonuclease I and their expression in Chinese systemic lupus erythematosus patients.
Chinese medical journal - 1 Nov 2004
Feng Xue-Bing, Shen Nan, Qian Jie, Sun Li, Hua Jing, Chen Shun-le
Abstract excerpt
BACKGROUND: Previous studies have suggested that interrupted clearance of nuclear DNA-protein complexes after cell death might initiate and propagate systemic lupus erythematosus (SLE). Deoxyribonuclease I (DNaseI) may be responsible for the removal of DNA from nuclear antigens at sites of high c...
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