Article
Longitudinal Cognitive Changes in Genetic Frontotemporal Dementia Within the GENFI Cohort.
Neurology - 19 Jul 2022
Poos Jackie M, MacDougall Amy, van den Berg Esther, Jiskoot Lize C, Papma Janne M, van der Ende Emma L, Seelaar Harro, Russell Lucy L, Peakman Georgia, Convery Rhian, Pijnenburg Yolande A L, Moreno Fermin, Sanchez-Valle Raquel, Borroni Barbara, Laforce Robert, Doré Marie-Claire, Masellis Mario, Tartaglia Maria Carmela, Graff Caroline, Galimberti Daniela, Rowe James B, Finger Elizabeth, Synofzik Matthis, Vandenberghe Rik, Mendonça Alexandre, Tiraboschi Pietro, Santana Isabel, Ducharme Simon, Butler Christopher, Gerhard Alexander, Levin Johannes, Danek Adrian, Otto Markus, Le Ber Isabelle, Pasquier Florence, van Swieten John, Rohrer Jonathan D
Abstract excerpt
BACKGROUND AND OBJECTIVES: Disease-modifying therapeutic trials for genetic frontotemporal dementia (FTD) are underway, but sensitive cognitive outcome measures are lacking. The aim of this study was to identify such cognitive tests in early stage FTD by investigating cognitive decline in a large cohort of genetic FTD pathogenic variant carriers and by investigating whether gene-specific differences are moderated...
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