Article
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.
Cancer discovery - 1 Oct 2016
Kühn Michael W M, Song Evelyn, Feng Zhaohui, Sinha Amit, Chen Chun-Wei, Deshpande Aniruddha J, Cusan Monica, Farnoud Noushin, Mupo Annalisa, Grove Carolyn, Koche Richard, Bradner James E, de Stanchina Elisa, Vassiliou George S, Hoshii Takayuki, Armstrong Scott A
Abstract excerpt
Homeobox (HOX) proteins and the receptor tyrosine kinase FLT3 are frequently highly expressed and mutated in acute myeloid leukemia (AML). Aberrant HOX expression is found in nearly all AMLs that harbor a mutation in the Nucleophosmin (NPM1) gene, and FLT3 is concomitantly mutated in approximately 60% of these cases. Little is known about how mutant NPM1 (NPM1mut) cells maintain aberrant gene expression. Here, we...
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