Article
Increased Prevalence of Rare Copy Number Variants in Treatment-Resistant Psychosis.
Schizophrenia bulletin - 4 Jul 2023
Farrell Martilias, Dietterich Tyler E, Harner Matthew K, Bruno Lisa M, Filmyer Dawn M, Shaughnessy Rita A, Lichtenstein Maya L, Britt Allison M, Biondi Tamara F, Crowley James J, Lázaro-Muñoz Gabriel, Forsingdal Annika E, Nielsen Jacob, Didriksen Michael, Berg Jonathan S, Wen Jia, Szatkiewicz Jin, Mary Xavier Rose, Sullivan Patrick F, Josiassen Richard C
Abstract excerpt
BACKGROUND: It remains unknown why ~30% of patients with psychotic disorders fail to respond to treatment. Previous genomic investigations of treatment-resistant psychosis have been inconclusive, but some evidence suggests a possible link between rare disease-associated copy number variants (CNVs) and worse clinical outcomes in schizophrenia. Here, we identified schizophrenia-associated CNVs in patients with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.