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Article

Age at menarche, age at natural menopause, and risk of rheumatoid arthritis - a Mendelian randomization study.

Arthritis research & therapy - 9 Apr 2021

Zhu Jingjing, Niu Zheng, Alfredsson Lars, Klareskog Lars, Padyukov Leonid, Jiang Xia

Abstract excerpt

BACKGROUND: Hormonal reproductive factors have been suggested to play an important role in the etiology of rheumatoid arthritis (RA), an autoimmune inflammatory disorder affecting primarily women. We conducted a two-sample Mendelian randomization (MR) study examining three relevant exposures, age at menarche (AAM), age at natural menopause (ANM), and age at first birth (AFB) with the risk of RA. METHODS: We...

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Identifiers

PMID: 33836822
DOI: 10.1186/s13075-021-02495-x
PMCID: PMC8034136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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