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Article

MITA oligomerization upon viral infection is dependent on its N-glycosylation mediated by DDOST

30 Nov 2022

Abstract excerpt

The mediator of IRF3 activation (MITA, also named STING) is critical for immune responses to abnormal cytosolic DNA and has been considered an important drug target in the clinical therapy of tumors and autoimmune diseases. In the present study, we report that MITA undergoes DDOST-mediated N-glycosylation in the endoplasmic reticulum (ER) upon DNA viral infection. Selective mutation of DDOST-dependent...

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PMID: 36449507
DOI: 10.1371/journal.ppat.1010989

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