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Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation

10 Jan 2022

Abstract excerpt

Zika virus (ZIKV) infection can be associated with neurological pathologies, such as microcephaly in newborns and Guillain-Barre syndrome in adults. Effective therapeutics are currently not available. As such, a comprehensive understanding of virus-host interactions may guide the development of medications for ZIKV. Here we report a human genome-wide overexpression screen to identify host factors that regulate...

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PMID: 35013224
DOI: 10.1038/s41467-021-27670-1

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