The telomere syndromes.

Abstract excerpt

There has been mounting evidence of a causal role for telomere dysfunction in a number of degenerative disorders. Their manifestations encompass common disease states such as idiopathic pulmonary fibrosis and bone marrow failure. Although these disorders seem to be clinically diverse, collectively they comprise a single syndrome spectrum defined by the short telomere defect. Here we review the manifestations and...

Topics

• Animals
• Genetic Association Studies
• Genetic Diseases, Inborn
• Genetic Predisposition to Disease
• Humans
• Models, Biological
• Quantitative Trait, Heritable
• Syndrome
• Telomere