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Integrated multi-omics profiling reveals the role of the DNA methylation landscape in shaping biological heterogeneity and clinical behaviour of metastatic melanoma

18 Jul 2025

Abstract excerpt

Abstract Background We developed an integrated multi-omics analysis in metastatic melanoma (MM) cohorts to associate DNA methylation profiles with tumor progression, survival, response to adjuvant immunotherapy, structure of the tumor immune microenvironment and transcriptional programs of immunity and melanoma differentiation. Methods Lesions ( n = 191) from a fully annotated, retrospective cohort of 165 AJCC...

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Share to Cutaneous Melanoma Detection and Management
Share to Epigenetics and DNA Methylation
Share to Immunotherapy and Immune Responses

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PMID: 40682094
DOI: 10.1186/s13046-025-03474-9

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