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Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles?

3 Feb 2025

Abstract excerpt

Despite significant advances in fertility preservation, no proven pharmacological options exist to protect ovarian primordial follicle reserve from chemotherapy-induced damage. Developing targeted gonadoprotective treatments will require an improved understanding of the molecular mechanisms underlying chemotherapy-induced primordial follicle depletion. While there is robust evidence that gonadotoxic chemotherapy...

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Share to Ovarian cancer diagnosis and treatment
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Share to Reproductive Biology and Fertility

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PMID: 39986689
DOI: 10.1093/humrep/deaf024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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