Article
Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes.
Cells - 8 Nov 2022
Al-Sabri Mohamed H, Behare Neha, Alsehli Ahmed M, Berkins Samuel, Arora Aadeya, Antoniou Eirini, Moysiadou Eleni I, Anantha-Krishnan Sowmya, Cosmen Patricia D, Vikner Johanna, Moulin Thiago C, Ammar Nourhene, Boukhatmi Hadi, Clemensson Laura E, Rask-Andersen Mathias, Mwinyi Jessica, Williams Michael J, Fredriksson Robert, Schiöth Helgi B
Abstract excerpt
The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for SIM. We observe that chronic fluvastatin treatment causes reduced general locomotion activity and climbing ability. In addition, transmission microscopy of dissected skeletal muscles of fluvastatin-treated flies reveals strong myofibrillar...
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