Article
An ARVC-5 Drosophila knock-in model reveals new functions of Tmem43 in lipid homeostasis.
Biology open - 15 Apr 2026
Jürgens Kai, Menzel Lena, Klinke Nora, Schäper Lisa, Ratnavadivel Sandra, Walter Stefan, Milting Hendrik, Meyer Heiko, Paululat Achim
Abstract excerpt
Arrhythmogenic right ventricular cardiomyopathy type 5 is caused by the missense mutation S358L in the gene TMEM43 in humans. To date, the molecular mechanisms underlying the disease remain poorly understood. We established a CRISPR/Cas9 knock-in Drosophila model carrying the orthologous Tmem43p.S333L mutation to investigate these mechanisms in vivo. The resulting flies were viable but displayed reduced lifespan,...
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