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Article

Engineering and production of streptokinase in a Bacillus subtilis expression-secretion system.

Applied and environmental microbiology - 1 Feb 1994

Wong S L, Ye R, Nathoo S

Abstract excerpt

Streptokinase is one of the major blood-clot-dissolving agents used in many medical treatments. With the cloned streptokinase gene (skc) available, production of the secreted streptokinase from various Bacillus subtilis strains was studied. The use of the six-extracellular-protease-deficient strain, WB600, greatly improved the production yield of the secreted streptokinase. A modified skc which has the original...

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Identifiers

PMID: 8135514
DOI: 10.1128/aem.60.2.517-523.1994
PMCID: PMC201342

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