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Article

Glutathione Transferase P1: Potential Therapeutic Target in Ovarian Cancer

16 Nov 2022

Abstract excerpt

Chemotherapy resistance of ovarian cancer, regarded as the most lethal malignant gynecological disease, can be explained by several mechanisms, including increased activity of efflux transporters leading to decreased intracellular drug accumulation, increased efflux of the therapeutic agents from the cell by multidrug-resistance-associated protein (MRP1), enhanced DNA repair, altered apoptotic pathways, silencing...

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PMID: 36422199
DOI: 10.3390/medicina58111660

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