Article
The relationship between LRP5 rs556442 and rs638051 polymorphisms and mutations and their influence on bone metabolism in postmenopausal Xinjiang women with type 2 diabetes.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Apr 2023
Li Jun, Song Minli, Li Siyuan, Wang Xiling, Zhao Huirong, Hou Zexin
Abstract excerpt
BACKGROUND: The Wnt/β-catenin signaling pathway plays a crucial role in bone development and metabolism. The low-density lipoprotein receptor-related protein 5 (LRP5), an important receptor in the Wnt signaling pathway, promotes the osteogenesis of osteoblasts and curbs bone resorption by osteoclasts. OBJECTIVES: To determine the expression of LRP5 polymorphisms (rs556442 and rs638051) and their relationship with...
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