Relationship between polymorphisms and mutations at rs7125942 and rs3736228 of LRP5 gene and bone metabolism in postmenopausal women.

doi:10.1186/s13018-024-04579-1

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Article

Relationship between polymorphisms and mutations at rs7125942 and rs3736228 of LRP5 gene and bone metabolism in postmenopausal women.

Journal of orthopaedic surgery and research - 1 Feb 2024

Li Jun, Li Ya, Li Siyuan, Lu Yunqiu, Rai Partab

Abstract excerpt

OBJECTIVE: To analyze the relationship between the polymorphism and mutation of rs7125942 and rs3736228 locus in the low-density lipoprotein receptor-related protein 5 (LRP5) genotype and bone mineral density (BMD) in postmenopausal women in Xinjiang, China, to provide a basis for prevention and treatment of the disease. METHODS: According to the results of dual-energy X-ray (DEXA) determination of BMD, the 136...

Topics

Humans
Female
Low Density Lipoprotein Receptor-Related Protein-5
Postmenopause
Bone Density
Polymorphism, Genetic
Mutation
Osteoporosis, Postmenopausal

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Identifiers

PMID: 38302983
DOI: 10.1186/s13018-024-04579-1
PMCID: PMC10832214

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