Article
CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype.
Oncogene - 1 Jan 2023
Zeng Wenfeng, Xiong Lixiong, Wu Wei, Li Shunrong, Liu Jiang, Yang Linbing, Lao Liyan, Huang Penghan, Zhang Mengmeng, Chen Huiping, Miao Nanyan, Lin Zhirong, Liu Zifei, Yang Xinyu, Wang Jiayi, Wang Pei, Song Erwei, Yao Yandan, Nie Yan, Chen Jianing, Huang Di
Abstract excerpt
The heterogeneity of cancer-associated fibroblasts (CAFs) might be ascribed to differences in origin. CD10 and GPR77 have been reported to identify a chemoresistance-inducing CAF subset in breast cancer. However, the precise mechanism for the formation of the CD10+GPR77+ CAFs remains unknown. In this study, we found that CCL18 expression was positively correlated with the density of CD10+GPR77+ CAFs in breast...
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