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Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics.

Biochemical pharmacology - 1 Jul 2021

Zeng Li, Li Dongying, Tong Weida, Shi Tieliu, Ning Baitang

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Three viral proteins, the spike protein (S) for attachment of virus to host cells, 3-chymotrypsin-like cysteine protease (Mpro) for digestion of viral polyproteins to functional proteins, and RNA-dependent-RNA-polymerase (RdRp) for RNA synthesis are the most critical proteins for virus infection and replication, rendering...

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Antiviral Agents
COVID-19
COVID-19 Drug Treatment
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Spike Glycoprotein, Coronavirus

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PMID: 33482149
DOI: 10.1016/j.bcp.2021.114424
PMCID: PMC7816569

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