Article
Multiple sclerosis etiology: beyond genes and environment.
Expert review of clinical immunology - 1 May 2010
Mechelli Rosella, Annibali Viviana, Ristori Giovanni, Vittori Danila, Coarelli Giulia, Salvetti Marco
Abstract excerpt
Multiple sclerosis (MS) is a disorder of the CNS with inflammatory and neurodegenerative components. The etiology is unknown, but there is evidence for a role of both genetic and environmental factors. Among the heritable factors, MHC class II genes are strongly involved, as well as genes coding for others molecules of immunological relevance, genes controlling neurobiological pathways and genes of unknown...
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