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Article

Recognition of Granzyme B‐generated autoantigen fragments in scleroderma patients with ischemic digital loss

1 Jul 2002

Abstract excerpt

OBJECTIVE: To examine whether autoantibodies recognizing granzyme B (GB)-cleaved autoantigens are associated with ischemic digital loss (IDL) in limited systemic sclerosis (SSc). METHODS: Fifteen of 19 patients with limited SSc and IDL were matched by age, sex, race, and duration of disease to controls with limited SSc but without IDL. The sera were used to immunoblot HeLa cell lysates and chromosome preparations...

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PMID: 12124872
DOI: 10.1002/art.10407

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