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Anti-centromere antibodies target centromere–kinetochore macrocomplex: a comprehensive autoantigen profiling

18 Nov 2020

Abstract excerpt

OBJECTIVES: Anti-centromere antibodies (ACAs) are detected in patients with various autoimmune diseases such as Sjögren's syndrome (SS), systemic sclerosis (SSc) and primary biliary cholangitis (PBC). However, the targeted antigens of ACAs are not fully elucidated despite the accumulating understanding of the molecular structure of the centromere. The aim of this study was to comprehensively reveal the...

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PMID: 33208344
DOI: 10.1136/annrheumdis-2020-218881

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