Article
Kruppel-like factor 1-GATA1 fusion protein improves the sickle cell disease phenotype in mice both in vitro and in vivo.
Blood - 24 Nov 2022
Zhu Jianqiong, Li Hongzhen, Aerbajinai Wulin, Kumkhaek Chutima, Pirooznia Mehdi, Saxena Ankit, Dagur Pradeep, Chin Kyung, Rodgers Griffin P
Abstract excerpt
Sickle cell disease (SCD) and β-thalassemia are among the most common genetic disorders worldwide, affecting global health and mortality. Hemoglobin A2 (HbA2, α2δ2) is expressed at a low level in adult blood due to the lack of the Kruppel-like factor 1 (KLF1) binding motif in the δ-globin promoter region. However, HbA2 is fully functional as an oxygen transporter, and could be a valid antisickling agent in SCD,...
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