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Article

Autoimmunity to a ribonucleoprotein drives neuron loss in multiple sclerosis models

23 May 2022

Abstract excerpt

Neurodegeneration, the progressive loss or damage to neurons and axons, underlies permanent disability in multiple sclerosis (MS); yet its mechanisms are incompletely understood. Recent data indicates autoimmunity to several intraneuronal antigens, including the RNA binding protein (RBP) heterogenous nuclear ribonucleoprotein A1 (hnRNP A1), as contributors to neurodegeneration. We previously showed that addition...

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PMID: 35618205
DOI: 10.1016/j.nbd.2022.105775

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