Article
Immune cells are increased in normal breast tissues of BRCA1/2 mutation carriers.
Breast cancer research and treatment - 1 Jan 2023
Ogony Joshua, Hoskin Tanya L, Stallings-Mann Melody, Winham Stacey, Brahmbhatt Rushin, Arshad Muhammad Asad, Kannan Nagarajan, Peña Alvaro, Allers Teresa, Brown Alyssa, Sherman Mark E, Visscher Daniel W, Knutson Keith L, Radisky Derek C, Degnim Amy C
Abstract excerpt
PURPOSE: Breast cancer risk is elevated in pathogenic germline BRCA 1/2 mutation carriers due to compromised DNA quality control. We hypothesized that if immunosurveillance promotes tumor suppression, then normal/benign breast lobules from BRCA carriers may demonstrate higher immune cell densities. METHODS: We assessed immune cell composition in normal/benign breast lobules from age-matched women with...
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