Article

Immune cell density differences in normal breast lobules of BRCA1/2 mutation carriers, women with benign breast disease and healthy research volunteers

2022-07-15

Abstract excerpt

<title>Abstract</title> <p>Purpose Breast cancer risk is elevated in pathogenic germline <italic>BRCA 1/2</italic> mutation carriers due to compromised DNA quality control and elevated mutagenic load. We hypothesized that if immunosurveillance promotes tumor suppression, then normal breast lobules from BRCA carriers may demonstrate higher immune cell densities. Methods We assessed immune cell composition in nor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 900d0d88-0103-5612-9406-ee586401adbd
DOI: 10.21203/rs.3.rs-1720667/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune cell density differences in normal breast lobules of BRCA1/2 mutation carriers, women with benign breast disease and healthy research volunteersDOI 10.21203/rs.3.rs-1720667/v1Read

Immune cells are increased in normal breast tissues of BRCA1/2 mutation carriers.Semantic proximity Read

Changes in immune Cell Types in Breast Suggest a Decline in Immune Surveillance and Increased Immunosuppression with AgeSemantic proximity Read

Multiplex Immunohistochemistry and High-Throughput Image Analysis for Evaluation of Spatial Tumor Immune Cell Markers in Human Breast Cancer: Preliminary Results from the Nashville Breast Health StudySemantic proximity Read

Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast CancerSemantic proximity Read

Cytotoxic T cell depletion with increasing epithelial abnormality in women with benign breast disease.Semantic proximity Read

Relation of Quantitative Histologic and Radiologic Breast Tissue Composition Metrics with Invasive Breast Cancer RiskSemantic proximity Read

High mammographic density in women is associated with protumor inflammation.Semantic proximity Read

Impact of <i>BRCA</i> mutation status on tumor infiltrating lymphocytes (TILs), response to treatment, and prognosis in breast cancer patients treated with neoadjuvant chemotherapySemantic proximity Read

Pathologic characteristics of breast parenchyma in patients with hereditary breast carcinoma, including BRCA1 and BRCA2 mutation carriers.Semantic proximity Read

Collagen density regulates the activity of tumor-infiltrating T cellsSemantic proximity Read

APOE+ Tumor-Associated Macrophages and CD4-DOCK4 T Cells Reveal Distinct Microenvironmental Features in HER2-Low and HER2-0 Hormone Receptor-Positive Breast CancerSemantic proximity Read

High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium.Semantic proximity Read